Folate Drug and Food Interactions

Folate Drug and Food Interactions

Many people who are taking supplementary folate in the form of folic acid are taking other medications or substances as well which are known to interact with folate. The following are some specific examples and the types of interactions that are most likely to occur. Various nutrients can also interact with folate. For example, aggressive treatment with folic acid can mask a still existing vitamin B12 deficiency. It can also lead to zinc deficiency.
              
If you have any questions about whether it would be advisable to adjust the dose of folic acid based on another medication you are taking, be sure to consult your doctor.
 
 
Medication or Substance                              Interactive Effect
 
            Analgesics                                                   Decrease effectiveness of folic acid.
 
            Antacids containing aluminum or                May decrease absorption of folic acid
 magnesium                                                  (Best to take folic acid two hours prior to
                                                                      taking the antacid.)
 
 Furosemide (Lasix): A potent diuretic          Decreases intestinal absorption of folate.
 
 Anticonvulsants used to treat epilepsy        Dosages of more than 1 mg of folic acid
                                                                      can interfere with the effectiveness of
                                                                      anticonvulsants.
 
 Methotrexate: Used to treat                          Interferes with THF synthesis. Folic acid
 rheumatoid arthritis and certain                    may also interfere with the effectiveness             cancers                                                         of methotrexate in treating
                                                                       lymphoblastic leukemia.
 
Cholestyramine: Cholesterol lowering           May interfere with absorption or activity
medication                                                     of folate.
 
Oral contraceptives                                        May interfere with absorption or activity
                                                                       of folate. May require additional folic
                                                                       acid or dietary folate.            
 
Aspirin and NSAIDs                                       May interfere with absorption or activity
                                                                       of folate.
 
Phenobarbitol: A barbiturate                          May interfere with absorption or activity
                                                                       of folate.         
 
Cortisone drugs                                              Decreases effectiveness of folic acid.
 
Epoetin: Used to treat anemia                        Decreases the effectiveness of folic acid.
 
Quinine: Fever reducing analgesic                 Decreases the effectiveness of folic acid.
Triamterene: A diuretic                                   Decreases the effectiveness of folic
                                                                        acid.
 
Trimethoprim: Treats urinary                          Decreases the effectiveness of folic
Infections.                                                       acid.
 
Pyrimethamine: Antimalarial drug                   Decreases the effectiveness of both.
 
 
Antibiotics such as tetracycline,                      May interfere with the absorption
Erythromycin, and sulfa drugs                         of folic acid. May also cause
                                                                         false low folate readings.
 
Chloramphenicol: Potent antibiotic                  Produces folic acid deficiency.
used to treat serious infections
 
Tobacco                                                           Decreases  absorption of folic acid.
 
Alcohol                                                             Causes  folic acid deficiency.